Publications
Selected publications. These are arranged in clusters for each major topic, and sorted to list most recent papers first. Work prior to 2014 is presented sparsely, or not at all. Review articles are collected in their own section.
Short cuts:
Drugs that slow aging or extend lifespan in mice
Harrison, D. E., R. Strong, P. Reifsnyder, N. Rosenthal, R. Korstanje, E. Fernandez, K. Flurkey, B. C. Ginsburg, M. D. Murrell, M. A. Javors, M. Lopez-Cruzan, J. F. Nelson, B. J. Willcox, R. Allsopp, D. M. Watumull, D. G. Watumull, G. Cortopassi, J. L. Kirkland, T. Tchkonia, Y. Choi, M. J. Yousefzadeh, P. D. Robbins, J. R. Mitchell, M. Acar, E. A. Sarnoski, M. R. Bene, A. Salmon, N. Kumar, R. A. Miller. 2023. Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used. GeroScience DOI: 10.1007/s11357-023-01011-0. PMID: 38041783.
Strong, R., R. A. Miller, C. J. Cheng, J. Nelson, J. Gelfond, S. Kesaraju Allani, V. Diaz, A. Olsen Dorigatti, J. Dorigatti, E. Fernandez, A. Galecki, B. Ginsburg, K. L. Hamilton, M. A. Javors, K. Kornfeld, M. Kaeberlein, S. Kumar, D. B. Lombard, M. Lopez-Cruzan, B. F. Miller, P. Rabinovitch, P. Reifsnyder, N. A. Rosenthal, M. A. Bogue , A. B. Salmon, Y. Suh, E. Verdin, H. Weissbach, J. Newman, F. Maccchiarini, D. E. Harrison. 2022. Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice. Aging Cell Sep 30:e13724 http://doi.org/10.1111/acel.13724. PMID: 36179270. PMC9741502.
Herrera, J. J., K. Pifer, S. Louzon, D. Leander, O. Fiehn, S. M. Day, R. A. Miller, M. Garratt. 2023. Early or late-life treatment with acarbose or rapamycin improve functional capacity and affect cardiac structure in aging mice. J. Gerontol. Biol. Sci. 78:397 – 406. doi: 10.1093/gerona/glac221. PMID: 36342748. PMC9977253.
Harrison, D. E., R. Strong, P. Reifsnyder, N. Kumar, E. Fernandez, K. Flurkey, M. Javors, M. Lopez-Cruzan, F. Macchiarini, J. F. Nelson, A. Bitto, A. L. Sindler, G. Cortopassi, K. Kavanagh, L. Leng, R. Bucala, N. Rosenthal, A. Salmon, T. M.Stearns, M. Bogue, R. A. Miller. 2021. 17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex. Aging Cell, Mar 31:e13328. DOI: 10.1111/acel.13328. PMID: 33788371.
Miller, R. A., D. E. Harrison, D. B. Allison, M. Bogue, L. Debarba, V. Diaz, E. Fernandez, A. Galecki., W. T. Garvey, H. Jayarathne, N. Kumar, M. A. Javors, W. C. Ladiges, F. Macchiarini, J. Nelson, P. Reifsnyder, N. A. Rosenthal, M. Sadagurski, A. B. Salmon, D. L. Smith, Jr., J. M. Snyder, D. B. Lombard, R. Strong. 2020. Canagliflozin extends lifespan in genetically heterogeneous male but not female mice. JCI Insight 2020 Sep 29:140019. doi: 10.1172/jci.insight.140019. PMID: 32990681. PMC7710304
Herrera, J. J., S. Louzon, K. Pifer, D. Leander, G. Merrihew, K. Szczesniak, J. Whitson, J. E. Wilkinson, O. Fiehn, M. MacCoss, S. M. Day, R. A. Miller, and M. Garratt. 2020. Acarbose has sex-dependent and independent effects on age-related physical function, cardiac health and lipid biology. JCI Insight Sep 29;137474. doi: 10.1172/jci.insight.137474. PMID: 32990683.
Strong, R., R. A. Miller, M. Bogue, E. Fernandez, M. A. Javors, S. Libert, P. A. Marinez, M. P. Murphy, N. Musi, J. F. Nelson, M. Petraschec, P. Reifsnyder, A. Richardson, A. B. Salmon, F. Macchiarini, D. E. Harrison. 2020. Rapamycin-mediated mouse lifespan extension: late-life dosage regimes with sex-specific effects. Aging Cell:e13269. https://doi.org/10.1111/acel.13269. PMID: 33145977.
Harrison, D. E., R. Strong, P. Reifsnyder, N. Kumar, E. Fernandez, K. Flurkey, M. Javors, M. Lopez-Cruzan, F. Macchiarini, J. F. Nelson, A. Bitto, A. L. Sindler, G. Cortopassi, K. Kavanagh, L. Leng, R. Bucala, N. Rosenthal, A. Salmon, T. M.Stearns, M. Bogue, R. A. Miller. 2021. 17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex. Aging Cell, Mar 31:e13328. DOI: 10.1111/acel.13328. PMID: 33788371.
Garratt, M., D. Leander, K. Pifer, B. Bower, J. J. Herrera, S. M. Day, O. Fiehn,. S. V. Brooks, R. A. Miller. 2019. 17-α estradiol ameliorates age-associated sarcopenia and improves late life physical function in male mice but not in females or castrated males. Aging Cell, DOI: 10.1111/acel.12920. PMID: 30740872.
Miller, R. A., D. E. Harrison, C. M. Astle, M. A. Bogue, J. Brind, E. Fernandez, K. Flurkey, M. Javors, W. Ladiges, C. Leeuwenburgh, F. Macchiarini, J. Nelson, A. G. Ryazanov, J. Snyder, T. M. Stearns, D. E. Vaughan, and R. Strong. 2019. Glycine supplementation extends lifespan of male and female mice. Aging Cell DOI:10.1111/acel.12953. PMID: 30916479.
Harrison, D. E., R. Strong, S. Alavez, C. M. Astle, J. DiGiovanni, E. Fernandez, K. Flurkey, M. A. Javors, M. Levi, G. J. Lithgow, F. Macchiarini, J. F. Nelson, S. J. Sukoff Rizzo, T. J. Slaga, T. Stearns, J. E. Wilkinson, R. A. Miller. 2019. Acarbose improves health and lifespan in aging HET3 mice. Aging Cell, in press. DOI: 10.1111/acel.12898. PMID: 306880027.
Garratt, M., K. A. Lagerborg, Y.-M. Tsai, A. Galecki, M. Jain, R. A. Miller. 2018. Male lifespan extension with 17-α estradiol is linked to a sex-specific metabolomic response modulated by gonadal hormones in mice. Aging Cell http://dx.doi.org/10.1111/acel.12786. PMID: 29806096.
Garratt, M., B. Bower, G. G. Garcia, R. A. Miller. 2017. Sex-differences in lifespan-extension with acarbose and 17-α estradiol: gonadal hormones underlie male-specific improvements in glucose tolerance and mTORC2 signaling. Aging Cell 16:1256-1266. doi: 10.1111/acel.12656. PMID: 28834262.
Strong, R., R. A. Miller, A. Antebi, C. M. Astle, M. Bogue, M. S. Denzel, E. Fernandez, K. Flurkey, K. L. Hamilton, D. W. Lamming, M. A. Javors, J. P. de Magalhães, J. M. McCord, B. F. Miller, M. Müller, J. F. Nelson, J. Ndukum, G. E.. Rainger, A. Richardson, D. M. Sabatini, A. B. Salmon, J. W. Simpkins, W. T. Steegenga, N. L. Nadon, D. E. Harrison. 2016. Longer lifespan in male mice treated with a non-feminizing steroid, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell 15: 872 - 884. doi: 10.1111/acel.12496. PMID: 27312235
Miller, R. A., D. E. Harrison, C. M. Astle, E. Fernandez, K. Flurkey, M. Han, M. A. Javors, X. Li, N. L. Nadon, J. F. Nelson, S. Pletcher, A. B. Salmon, Z. D. Sharp, S. Van Roekel, L. Winkleman, R. Strong. 2014. Rapamycin-mediated lifespan increase in mice is dose and sex-dependent and metabolically distinct from dietary restriction. Aging Cell 13:468-477. [PMID:24341993]
Harrison, D. E., R. Strong, D. B. Allison, B. N. Ames, C. M. Astle, H. Atamna, E. Fernandez, K. Flurkey, M. A. Javors, N. L. Nadon, J. F. Nelson, J. W. Simpkins, D. Smith, J. E. Wilkinson, and R. A. Miller. 2014. Acarbose, 17--estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell 13:273-282 PMID: 24245565
Wilkinson, J. E., L. Burmeister, S. V. Brooks, C.-C. Chan, S. Friedline, D. E. Harrison, J. F. Hejtmancik, N. Nadon, R. Strong, L. K. Wood, M. A.Woodward, and R. A. Miller. 2012. Rapamycin slows aging in mice. Aging Cell 11: 675 – 682. PMID 22587563
Harrison, D. E., R. Strong, Z. D. Sharp, J. F. Nelson, C. M. Astle, K. Flurkey, N. L. Nadon, J. E. Wilkinson, K. Frenkel, C. S. Carter, M. Pahor, M. Javors, E. Fernandez, and R. A. Miller. 2009. Rapamycin fed from 20 months of age extends lifespan in genetically heterogeneous mice. Nature 460: 392 - 395. PMID: 19587680
Miller, R. A., G. Buehner, Y. Chang, J. M. Harper, R. Sigler, and M. Smith-Wheelock. 2005. Methionine-deficient diet extends mouse life span, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 4:199-125.
Harrison, D. E., R. Strong, S. Alavez, C. M. Astle, J. DiGiovanni, E. Fernandez, K. Flurkey, M. A. Javors, M. Levi, G. J. Lithgow, F. Macchiarini, J. F. Nelson, S. J. Sukoff Rizzo, T. J. Slaga, T. Stearns, J. E. Wilkinson, R. A. Miller. 2019. Acarbose improves health and lifespan in aging HET3 mice. Aging Cell, in press. DOI: 10.1111/acel.12898. PMID: 306880027.
Garratt, M., K. A. Lagerborg, Y.-M. Tsai, A. Galecki, M. Jain, R. A. Miller. 2018. Male lifespan extension with 17-α estradiol is linked to a sex-specific metabolomic response modulated by gonadal hormones in mice. Aging Cell http://dx.doi.org/10.1111/acel.12786. PMID: 29806096.
Garratt, M., B. Bower, G. G. Garcia, R. A. Miller. 2017. Sex-differences in lifespan-extension with acarbose and 17-α estradiol: gonadal hormones underlie male-specific improvements in glucose tolerance and mTORC2 signaling. Aging Cell 16:1256-1266. doi: 10.1111/acel.12656. PMID: 28834262.
Strong, R., R. A. Miller, A. Antebi, C. M. Astle, M. Bogue, M. S. Denzel, E. Fernandez, K. Flurkey, K. L. Hamilton, D. W. Lamming, M. A. Javors, J. P. de Magalhães, J. M. McCord, B. F. Miller, M. Müller, J. F. Nelson, J. Ndukum, G. E.. Rainger, A. Richardson, D. M. Sabatini, A. B. Salmon, J. W. Simpkins, W. T. Steegenga, N. L. Nadon, D. E. Harrison. 2016. Longer lifespan in male mice treated with a non-feminizing steroid, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell 15: 872 - 884. doi: 10.1111/acel.12496. PMID: 27312235
Miller, R. A., D. E. Harrison, C. M. Astle, E. Fernandez, K. Flurkey, M. Han, M. A. Javors, X. Li, N. L. Nadon, J. F. Nelson, S. Pletcher, A. B. Salmon, Z. D. Sharp, S. Van Roekel, L. Winkleman, R. Strong. 2014. Rapamycin-mediated lifespan increase in mice is dose and sex-dependent and metabolically distinct from dietary restriction. Aging Cell 13:468-477. [PMID:24341993]
Harrison, D. E., R. Strong, D. B. Allison, B. N. Ames, C. M. Astle, H. Atamna, E. Fernandez, K. Flurkey, M. A. Javors, N. L. Nadon, J. F. Nelson, J. W. Simpkins, D. Smith, J. E. Wilkinson, and R. A. Miller. 2014. Acarbose, 17--estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell 13:273-282 PMID: 24245565
Wilkinson, J. E., L. Burmeister, S. V. Brooks, C.-C. Chan, S. Friedline, D. E. Harrison, J. F. Hejtmancik, N. Nadon, R. Strong, L. K. Wood, M. A.Woodward, and R. A. Miller. 2012. Rapamycin slows aging in mice. Aging Cell 11: 675 – 682. PMID 22587563
Harrison, D. E., R. Strong, Z. D. Sharp, J. F. Nelson, C. M. Astle, K. Flurkey, N. L. Nadon, J. E. Wilkinson, K. Frenkel, C. S. Carter, M. Pahor, M. Javors, E. Fernandez, and R. A. Miller. 2009. Rapamycin fed from 20 months of age extends lifespan in genetically heterogeneous mice. Nature 460: 392 - 395. PMID: 19587680
Miller, R. A., G. Buehner, Y. Chang, J. M. Harper, R. Sigler, and M. Smith-Wheelock. 2005. Methionine-deficient diet extends mouse life span, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 4:199-125.
Mechanisms of stress resistance in slow-aging mice
Jayarathne, H. S. M., L K. Debarba, J. J. Jaboro, R A. Miller, M. Sadagurski. 2022. Neuroprotective effects of Canagliflozin: lessons from aged genetically diverse UM-HET3 mice. Aging Cell, DOI: 10.1111/acel.13653. PMID: 35707855.
Li, X., M. McPherson, M. Hager, Y. Fang, A. Bartke, R. A. Miller. 2022. Transient early life growth hormone exposure alters brain, muscle, liver, macrophages, and adipocytes in long-lived Ames dwarf mice. FASEB J., doi: 10.1096/fj.202200143R. PMID: 35704312.
Wink, L., R. A. Miller, G. G. Garcia. 2022. Rapamycin, acarbose, and 17a-estradiol share common mechanisms regulating the MAPK signaling pathways involved in hormonal signaling and inflammation. Immunity and Ageing. DOI: 10.1186/s12979-022-00264-1. PMID: 35105357.
Debarba, L. K., H. Jayarathne, R. A. Miller, M. Garratt, M. Sadagurski. 2021. 17-a-estradiol has sex-specific effects on neuroinflammation that are partly reversed by gonadectomy. J. Gerontol. Biol. Sci. 77:66-74. doi: 10.1093/gerona/glab216. PMID: 34309657.
Endicott, S. J., A. C. Monovich, E. L. Huang, E. I. Henry, D. N. Boynton, Jr., L. J. Beckmann, M. J. MacCoss, R. A. Miller. 2021. Lysosomal targetomics in ghr KO mice reveals a role for enhanced chaperone-mediated autophagy in shaping specific molecular pathways. Autophagy DOI: 10.1080/15548627.2021.1990670. PMID: 34704522.
Shen, Z., A. Hinson, R. A. Miller, G. G. Garcia. 2021. Cap-independent translation: a shared mechanism for lifespan extension by rapamycin, acarbose, and 17a-estradiol. Aging Cell 20(5):e13345. DOI: 10.1111/acel.13345. PMID: 33742521. PMC8135077 DOI: 10.1111/acel.13345
Endicott, S. J., D. N. Boynton, Jr., L. J. Beckmann, and R. A. Miller. 2021. Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy. Autophagy 17:612-625. doi: 10.1080/15548627.2020.1725378 PMID: 32013718, PMC8032237
Li, X., J. A. Frazier, E. Spahiu, M. McPherson, and R. A. Miller. 2020, Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice. Aging 12: 8677 – 8789. PMID: 32464603 PMC7288969.
Endicott, S. J., Z. J. Ziemba, L. J. Beckmann, D. N. Boynton, and R. A. Miller. 2020. Inhibition of class I PI3K enhances chaperone-mediated autophagy. J. Cell Biol. 219 (12): e202001031. https://doi.org/10.1083/jcb.202001031. PMID: 33048163. PMC7557678.
Lombard, D. B., W. Kohler, A. H. Guo, C. Gendron, M. Han, W. Ding, Y. Lyu, T.T. Ching, F. Y. Want, T. Chakraborty, X. Li, X. Shi, Z. Nikolovska-Coleska, Y. Duan, T. Girke, A.-L. Hsu, S. D. Pletcher, and R. A. Miller. 2020. High throughput small molecule screening reveals NRF2-dependent and independent pathways of cellular stress resistance. Science Advances 6 : eaaz7628. https://www.biorxiv.org/content/10.1101/778548v1 PMID: 33008901 PMC7852388
Ozkurede, U., and R. A. Miller. 2019. Improved mitochondrial stress response in long-lived Snell dwarf mice. Aging Cell. e13030. https ://doi.org/10.1111/acel.13030. PMID: 31423721.
Ozkurede, U., R. Kala, C. Johnson, Z. Shen, R. A. Miller, and G. G. Garcia. 2019. Cap-independent mRNA translation is upregulated in long-lived endocrine mutant mice. J. Molec. Endo. 63:123-138. https://doi.org/10.1530/JME-19-0021. PMID: 31357177
Dominick, G., J. Bowman, X. Li, R. A. Miller and G. Garcia. 2017. mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GRKO, and PAPPA-KO mice. Aging Cell 16:52-60. doi: 10.1111/acel.12525. PMID: 27618784.
Sadagurski, M., T. Landeryou, G. Cady, J. J. Kopchick, E. O. List, D. E. Berryman, A. Bartke, and R. A. Miller. 2015. Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice. Aging Cell doi: 10.1111/acel.12382. PMID: 26268661
Li, W., X. Li, and R. A. Miller. 2014. ATF4 activity: a common feature shared by many kinds of slow-aging mice. Aging Cell 13:1012- 1018. PMID: 25156122.
Dominick, G., D. Berryman, E. List, J. Kopchick, X.Li, R. A. Miller, and G. G. Garcia. 2015. Regulation of mTOR activity in Snell dwarf and growth hormone receptor knockout mice. Endocrinology 156:565-575. PMID: 25456069
Li, X., A. Bartke, D. E. Berryman, K. Funk, J. J. Kopchick, E. O. List, L. Sun, and R. A. Miller. 2013. Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes. American Journal of Physiology: Endocrinology and Metabolism 15:E942-950. PMID: 23941873
Steinbaugh, M. J., L. Y. Sun, A. Bartke, and R. A. Miller. 2012. Activation of genes involved in xenobiotic metabolism: a shared signature in mouse models of extended longevity. American J. Physiology: Endocrinology and Metabolism 303:E488 – E495. [PMID 222693205]
Salmon, A. B., S. Murakami, A. Bartke, J. Kopchick, K. Yasumura, and R. A. Miller. 2005. Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. American Journal of Physiology: Endocrinology and Metabolism 289:E23-E29.
Ozkurede, U., R. Kala, C. Johnson, Z. Shen, R. A. Miller, and G. G. Garcia. 2019. Cap-independent mRNA translation is upregulated in long-lived endocrine mutant mice. J. Molec. Endo. 63:123-138. https://doi.org/10.1530/JME-19-0021. PMID: 31357177
Dominick, G., J. Bowman, X. Li, R. A. Miller and G. Garcia. 2017. mTOR regulates the expression of DNA damage response enzymes in long-lived Snell dwarf, GRKO, and PAPPA-KO mice. Aging Cell 16:52-60. doi: 10.1111/acel.12525. PMID: 27618784.
Sadagurski, M., T. Landeryou, G. Cady, J. J. Kopchick, E. O. List, D. E. Berryman, A. Bartke, and R. A. Miller. 2015. Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice. Aging Cell doi: 10.1111/acel.12382. PMID: 26268661
Li, W., X. Li, and R. A. Miller. 2014. ATF4 activity: a common feature shared by many kinds of slow-aging mice. Aging Cell 13:1012- 1018. PMID: 25156122.
Dominick, G., D. Berryman, E. List, J. Kopchick, X.Li, R. A. Miller, and G. G. Garcia. 2015. Regulation of mTOR activity in Snell dwarf and growth hormone receptor knockout mice. Endocrinology 156:565-575. PMID: 25456069
Li, X., A. Bartke, D. E. Berryman, K. Funk, J. J. Kopchick, E. O. List, L. Sun, and R. A. Miller. 2013. Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes. American Journal of Physiology: Endocrinology and Metabolism 15:E942-950. PMID: 23941873
Steinbaugh, M. J., L. Y. Sun, A. Bartke, and R. A. Miller. 2012. Activation of genes involved in xenobiotic metabolism: a shared signature in mouse models of extended longevity. American J. Physiology: Endocrinology and Metabolism 303:E488 – E495. [PMID 222693205]
Salmon, A. B., S. Murakami, A. Bartke, J. Kopchick, K. Yasumura, and R. A. Miller. 2005. Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. American Journal of Physiology: Endocrinology and Metabolism 289:E23-E29.
Comparative cellular biogerontology – studies across species
Pickering, A. M., M. Lehr, C. M Gendron, S. D Pletcher, R. A Miller. 2017. Mitochondrial Thioredoxin Reductase 2 is elevated in long‐lived primate and rodent species and in long‐lived mutant mice, and extends fly lifespan. Aging Cell 16:683-692. PMID: 28474396.
Pickering, A. M., M. Lehr, W. Kohler, M. Han and R. A. Miller. 2015. Fibroblasts from longer lived species of primates, rodents, bats, carnivores and birds resist protein damage. J. Gerontol. Biol. Sci. 70: 791-799. doi: 10.1093/gerona/glu115. PMID: 25070662. PMC4481684.
Pickering, A. M., M. Lehr, and R. A. Miller. 2015. Lifespan of mice and primates correlates with immunoproteasome expression. J. Clin. Investigation 125:2059-2068. PMID: 25866968. PMC4463211.
Elbourkadi, N., S. N. Austad, and R. A. Miller. 2014. Fibroblasts from long-lived species of mammals and birds show delayed, but prolonged, phosphorylation of ERK. Aging Cell 13:283 - 291. [PMID: 24219321]
Harper, J. M., A. B. Salmon, S. F. Leiser, A. T. Galecki, and R. A. Miller. 2007. Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone. Aging Cell 6:1-13. PMID: 17156084
Pickering, A. M., M. Lehr, C. M Gendron, S. D Pletcher, R. A Miller. 2017. Mitochondrial Thioredoxin Reductase 2 is elevated in long‐lived primate and rodent species and in long‐lived mutant mice, and extends fly lifespan. Aging Cell 16:683-692. PMID: 28474396.
Pickering, A. M., M. Lehr, W. Kohler, M. Han and R. A. Miller. 2015. Fibroblasts from longer lived species of primates, rodents, bats, carnivores and birds resist protein damage. J. Gerontol. Biol. Sci. 70: 791-799. doi: 10.1093/gerona/glu115. PMID: 25070662. PMC4481684.
Pickering, A. M., M. Lehr, and R. A. Miller. 2015. Lifespan of mice and primates correlates with immunoproteasome expression. J. Clin. Investigation 125:2059-2068. PMID: 25866968. PMC4463211.
Elbourkadi, N., S. N. Austad, and R. A. Miller. 2014. Fibroblasts from long-lived species of mammals and birds show delayed, but prolonged, phosphorylation of ERK. Aging Cell 13:283 - 291. [PMID: 24219321]
Harper, J. M., A. B. Salmon, S. F. Leiser, A. T. Galecki, and R. A. Miller. 2007. Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone. Aging Cell 6:1-13. PMID: 17156084
Systems biology collaborations
Watanabe, K. T. Wilmanski, P. Baloni, M. Robinson, G. G. Garcia, M. R. Hoopmann, M. K. Midha, D. H. Baxter, M. Maes, S. R. Morrone, K. M. Crebs, C. Kapil, U. Kusebauch, J. Wiedrick, J. Lapidus, L. Pflieger, C. Laustad, J. C. Roach, G. Glusman, S. R. Cummings, N. J. Schork, N. D. Price, L Hood, R. A. Miller, R. L. Moritz, and N. Rappaport. 2023. Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers. Commun Biol 6:768. doi: 10.1038/s42003-023-05128-y. PMID: 37481675 PMCID: PMC10363145.
Bou Sleiman, M., S. Roy, M. C. Sadler, G. V. G. von Alvensleben, H. Li, S. Sen, D. E. Harrison, J. F. Nelson, R. Strong, R. A. Miller, Z. Kutalik, R.. W. Williams, J. Auwerx. 2022. Sex- and age-dependent genetics of longevity in a heterogeneous mouse population. Science 377, eabo3191 (2022). DOI: 10.1126/science.abo3191. PMID: 36173858. PMCID: 9905652.
Lu, J. Y., M. Simon, Y. Zhao, J. Ablaeva, N. Corson, Y. Choi, N. Schork, W. R. Hood, G. E. Hill, R. A. Miller, A. Seluanov, V. Gorbunova. 2022. Comparative transcriptomics reveals circadian rhythm and somatic reprogramming as two pillars of longevity regulation. Cell Metabolism, in press. doi.org/10.1016/j.cmet.2022.04.011.
Smith, B. J., R. A. Miller, T. M. Schmidt. 2021. Muribaculaceae genomes assembled from metagenomes suggest genetic drivers of differential response to acarbose treatment in mice. BioRxiv doi: https://doi.org/10.1101/2020.07.01.183202. mSphere 6:e0085121. doi: 10.1128/msphere.00851-21. PMID: 34851167. PMC8636109.
Lu, Y.-X., J. C. Regan, J. Eber, L. F. Drews, T. Weinseis, J. Stinn, O. Hahn, R. A. Miller, S. Grönke, L Partridge. 2021. A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to promote healthy longevity. eLife 10:e62233. PMID: 33988501. PMC8186904. DOI: 10.7554/eLife.62233
Roy, S., M. B. Sleiman, P. Jha, J. F. Ingels, C. J. Chapman, M. S. McCarty, J. D. Ziebarth, M. Hook, A. Sun, W. Zhao, J. Huang, S. M. Neuner, L. A. Wilmott, T. M. Shapaker, A. G. Centeno, D. G. Ashbrook, M. K. Mulligan, C. C. Kaczorowski, L. Makowski, Y. Cui, R. W. Read, R. A. Miller, K. Mozhui, E. G. Williams, S. Sen, L. Lu, J. Auwerx, R. W. Williams.
2021. Gene-by-environmental modulation of longevity and weight gain in the murine BXD family. Nature Metabolism, in press..
2021. Gene-by-environmental modulation of longevity and weight gain in the murine BXD family. Nature Metabolism, in press..
Duan, Yuzhu, D. Evans, R. Miller; N. Schork, S. Cummings, T. Girke. 2020. Signature Search: environment for gene expression signature searching and functional interpretation. Nucleic Acid Research 48:e124 doi: 10.1093/nar/gkaa878. PMID: 33068417 PMC7708038
Tyshkovskiy, A., A. A. Borodinova, G. P. Ables, M. Garratt, P. Khaitovich, R. A. Miller, V. N. Gladyshev. 2019. Identification and application of gene expression signatures of lifespan-extending interventions. Cell Metabolism, DOI:10.1016/j.cmet.2019.06.018. PMID: 31353263.
Smith, B. J., R. A. Miller, A. C. Ericsson, D. E. Harrison, R. Strong, T. M. Schmidt. 2019. Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice. bioRxiv 311456; DOI: 10.1186/s12866-019-1494-7 BMC Microbiology 19:130.. PMID: 31195972.
Ma, S., A. Upneja, A. Galecki, Y.-M. Tsai, C. Burant, S. Raskind, Q. Zhang, Z. D. Zhang, A. Seluanov, V. Gorbunova, C. B. Clish, R. A. Miller, V. N. Gladyshev. 2016. Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity. eLife 2016;10.7554/eLife.19130. PMID: 27874830..
Petkovich, D. A., D. I. Podolskiy, A. V. Lobanov, S.-G. Lee, R. A. Miller and V. N. Gladyshev. 2017. Using DNA methylation profiling to evaluate biological age and longevity interventions. Cell Metabolism, dx.doi.org/10.1016/j.cmet.2017.03.016. PMID: 28380383. PMC5578459.
Ma, S., S. H. Yim, S. G. Lee, E. B. Kim, S.-R. Lee, K.-T. Chang, R. Buffenstein, K. N. Lewis, T. J. Park, R. A. Miller, C B. Clish, V. N. Gladyshev. 2015. Organization of the mammalian metabolome according to organ function, lineage specialization and longevity. Cell Metabolism 22:332-343. PMID: 26244935.
Smith, B. J., R. A. Miller, A. C. Ericsson, D. E. Harrison, R. Strong, T. M. Schmidt. 2019. Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice. bioRxiv 311456; DOI: 10.1186/s12866-019-1494-7 BMC Microbiology 19:130.. PMID: 31195972.
Ma, S., A. Upneja, A. Galecki, Y.-M. Tsai, C. Burant, S. Raskind, Q. Zhang, Z. D. Zhang, A. Seluanov, V. Gorbunova, C. B. Clish, R. A. Miller, V. N. Gladyshev. 2016. Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity. eLife 2016;10.7554/eLife.19130. PMID: 27874830..
Petkovich, D. A., D. I. Podolskiy, A. V. Lobanov, S.-G. Lee, R. A. Miller and V. N. Gladyshev. 2017. Using DNA methylation profiling to evaluate biological age and longevity interventions. Cell Metabolism, dx.doi.org/10.1016/j.cmet.2017.03.016. PMID: 28380383. PMC5578459.
Ma, S., S. H. Yim, S. G. Lee, E. B. Kim, S.-R. Lee, K.-T. Chang, R. Buffenstein, K. N. Lewis, T. J. Park, R. A. Miller, C B. Clish, V. N. Gladyshev. 2015. Organization of the mammalian metabolome according to organ function, lineage specialization and longevity. Cell Metabolism 22:332-343. PMID: 26244935.
Review articles and essays
Miller, R. A., X. Li, G. Garcia. 2023. Aging rate indicators: speedometers for aging research in mice. Aging Biology, DOI:https://doi.org/10.59368/agingbio.20230003. PMID: 37694163. PMC10486275.
Bartke, A., L Y. Sun, X. Li, R. A. Miller. 2022. Early life interventions can shape aging. Front. Endocrinol. 13:797581. doi: 10.3389/fendo.2022.797581
Macchiarini, F., R. A. Miller, R. Strong, N. Rosenthal, D. E. Harrison. NIA interventions testing program: a collaborative approach for investigating interventions to promote healthy aging. 2021. In: Handbook of the Biology of Aging, 9th Edition. Eds: N. Musi, R. Hornsby. Academic Press. Chapter 10, pp. 219 – 236.
Lombard, D. B., R. A. Miller, and S. D. Pletcher. 2017. Biology of Aging and Longevity. Hazzard's Geriatric Medicine and Gerontology, 7th Edition. Eds: J. B. Halter, J. G. Ouslander, S. Studenski, K. P. High, S. Asthana, M. A. Supiano, C. Ritchie. Chapter 1, pages 3 - 24. McGraw-Hill, New York.
Nadon, N. L., R. Strong, R. A. Miller, D. E. Harrison. 2016. NIA Interventions Testing Program: investigating putative aging intervention agents in a genetically heterogeneous mouse model. eBiomedicine, dx.doi.org/10.1016/j.ebiom.2016.11.038. PMID: 27923560. PMC5514387.
Miller, R. A. 2016. Not your father's (or mother's) rodent: moving beyond B6. Neuron dx.doi.org/10.1016/j.neuron.2016.09.009. PMID: 27657444.
Lombard, D. B., and R. A. Miller. 2014. Aging, disease and longevity in mice. Annual Review of Gerontology and Geriatrics 34: 93 - 138. http://dx.doi.org/10.1891/0198-8794.34.93
Moorad, J. A., D. E. L. Promislow, N. Flesness, and R.A. Miller. 2012. A comparative assessment of univariate longevity measures using zoological animal records. Aging Cell 11:940-948. [PMID: 22805302]
Miller, R. A. Genes against aging. 2012. J. Gerontol. A Biol. Sci. Med. Sci. 67:495-502. [PMID 22459617]
Miller, R. A. 2009. "Dividends" from research on aging – can biogerontologists, at long last, find something useful to do? J Gerontol A Biol Sci Med Sci. 64:157-160. PMID: 19225032
Miller, R. A. 2009. Cell stress and aging: new emphasis on multiplex resistance mechanisms. J Gerontol A Biol Sci Med Sci. 64:179-82. [PMID: 19225033]
Lithgow, G. J. and R. A. Miller. 2008. The determination of aging rate by coordinated resistance to multiple forms of stress. In: The Molecular Biology of Aging, L.Guarente, L. Partridge, and D. Wallace, eds. Cold Spring Harbor Press, NY; Chapter 16, pp 427 – 481.
Miller, R. A. 2007. Of aging mice and men. Science 318: 390.
Olshansky, S. J., D. Perry, R. A. Miller, R. N. Butler. 2006. In pursuit of the longevity dividend: what should we be doing to prepare for the unprecedented aging of humanity? The Scientist, March, 2006, pp 28 – 36. Reprinted in: Unnatural Selection: The Challenges of Engineering Tomorrow's People (Eds. P. Healy and S. Rayner), Earthscan, London, pp. 95-102, 2009.
Miller, R. A. 2005. Evaluating evidence for aging. Science 310:441.
Warner, H., J. Anderson, S. Austad, E. Bergamini, D. Bredesen, R. Butler, B. A. Carnes, B. F. C. Clark, V. Cristofalo, J. Faulkner, L. Guarente, D. Harrison, T. Kirkwood, G. Lithgow, G. Martin, E. Masoro, S. Melov, R. A. Miller, S. J. Olshansky, L. Partridge, O. Pereira-Smith, T. Perls, A. Richardson, J. Smith, T. von Zglinicki, E. Wang, J. Y. Wei, and T. F. Williams. 2005. Science fact and the SENS agenda: What can we reasonably expect from ageing research? EMBO Reports 6:1006-1008.
Miller, R. A. 2005. The anti-aging sweepstakes: catalase runs for the ROSes. Science 308:1875-1876.
Miller, R. A., and S. N. Austad. 2006. Growth and aging: why do big dogs die young? Handbook of the Biology of Aging, 6th Edition. E. J. Masoro and S. N. Austad, Eds. Academic Press, NY. Chapter 19, pages 512 – 533.
Miller, R. A. 2002. Extending life: scientific prospects and political obstacles. Milbank Quarterly 80:155 – 174.
Miller, R. A. and S. Austad. 1999. Large animals in the fast lane (letter). Science 285:199.
Miller, R. A. 1999. Kleemeier Award Lecture: Are There Genes for Aging? J. Gerontology: Biological Sciences 54A:B297-B307.
Miller, R. A. 1999. Aging and Immune Function. In: Fundamental Immunology, Fourth Edition, W. E. Paul, Editor, Lippincott-Raven, Philadelphia. Chapter 28, pages 947 – 966.
Miller, R. A. 1997. When Will the Biology of Aging Become Useful? Future Landmarks in Biomedical Gerontology. J. American Geriatrics Soc. 45:1258-1267.
Lombard, D. B., and R. A. Miller. 2014. Aging, disease and longevity in mice. Annual Review of Gerontology and Geriatrics 34: 93 - 138. http://dx.doi.org/10.1891/0198-8794.34.93
Moorad, J. A., D. E. L. Promislow, N. Flesness, and R.A. Miller. 2012. A comparative assessment of univariate longevity measures using zoological animal records. Aging Cell 11:940-948. [PMID: 22805302]
Miller, R. A. Genes against aging. 2012. J. Gerontol. A Biol. Sci. Med. Sci. 67:495-502. [PMID 22459617]
Miller, R. A. 2009. "Dividends" from research on aging – can biogerontologists, at long last, find something useful to do? J Gerontol A Biol Sci Med Sci. 64:157-160. PMID: 19225032
Miller, R. A. 2009. Cell stress and aging: new emphasis on multiplex resistance mechanisms. J Gerontol A Biol Sci Med Sci. 64:179-82. [PMID: 19225033]
Lithgow, G. J. and R. A. Miller. 2008. The determination of aging rate by coordinated resistance to multiple forms of stress. In: The Molecular Biology of Aging, L.Guarente, L. Partridge, and D. Wallace, eds. Cold Spring Harbor Press, NY; Chapter 16, pp 427 – 481.
Miller, R. A. 2007. Of aging mice and men. Science 318: 390.
Olshansky, S. J., D. Perry, R. A. Miller, R. N. Butler. 2006. In pursuit of the longevity dividend: what should we be doing to prepare for the unprecedented aging of humanity? The Scientist, March, 2006, pp 28 – 36. Reprinted in: Unnatural Selection: The Challenges of Engineering Tomorrow's People (Eds. P. Healy and S. Rayner), Earthscan, London, pp. 95-102, 2009.
Miller, R. A. 2005. Evaluating evidence for aging. Science 310:441.
Warner, H., J. Anderson, S. Austad, E. Bergamini, D. Bredesen, R. Butler, B. A. Carnes, B. F. C. Clark, V. Cristofalo, J. Faulkner, L. Guarente, D. Harrison, T. Kirkwood, G. Lithgow, G. Martin, E. Masoro, S. Melov, R. A. Miller, S. J. Olshansky, L. Partridge, O. Pereira-Smith, T. Perls, A. Richardson, J. Smith, T. von Zglinicki, E. Wang, J. Y. Wei, and T. F. Williams. 2005. Science fact and the SENS agenda: What can we reasonably expect from ageing research? EMBO Reports 6:1006-1008.
Miller, R. A. 2005. The anti-aging sweepstakes: catalase runs for the ROSes. Science 308:1875-1876.
Miller, R. A., and S. N. Austad. 2006. Growth and aging: why do big dogs die young? Handbook of the Biology of Aging, 6th Edition. E. J. Masoro and S. N. Austad, Eds. Academic Press, NY. Chapter 19, pages 512 – 533.
Miller, R. A. 2002. Extending life: scientific prospects and political obstacles. Milbank Quarterly 80:155 – 174.
Miller, R. A. and S. Austad. 1999. Large animals in the fast lane (letter). Science 285:199.
Miller, R. A. 1999. Kleemeier Award Lecture: Are There Genes for Aging? J. Gerontology: Biological Sciences 54A:B297-B307.
Miller, R. A. 1999. Aging and Immune Function. In: Fundamental Immunology, Fourth Edition, W. E. Paul, Editor, Lippincott-Raven, Philadelphia. Chapter 28, pages 947 – 966.
Miller, R. A. 1997. When Will the Biology of Aging Become Useful? Future Landmarks in Biomedical Gerontology. J. American Geriatrics Soc. 45:1258-1267.
